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KMID : 0869120110130020179
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기초간호자연과학회지
2011 Volume.13 No. 2 p.179 ~ p.184
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Effect of Short-term Undernutrition on Hindlimb Muscles in Rats
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Choe Myoung-Ae
Lee Kyoung-A
An Gyeong-Ju
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Abstract
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Purpose:The purpose of this study was to examine the effect of short-term undernutrition on muscle weight and Type I and II fiber cross-sectional area of hindlimb muscles in undernourished rats.
Methods: Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The undernourished (UN) group (n=9) and the control (C) group (n=9). A control group was allowed to have water and pellet ad libitum for 5 days. Undernutrition was induced by providing 32% of total intake of the control group for 5 days. Body weight of two groups and food intake of the control group were measured every day. At 6 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles, and liver were dissected. Body weight, food intake, muscle weight, liver weight and cross-sectional area were determined.
Results:The UN group at 6 days after undernutrition showed significant decreases, as compared to the control group in body weight, liver weight, muscle weight of soleus, plantaris, and gastrocnemius, and Type I fiber cross-sectional area of soleus and gastrocnemius muscles and Type II fiber cross-sectional area of plantaris and gastrocnemius muscles.
Conclusion:Hindlimb muscle atrophy occurs from the short-term undernutrition.
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KEYWORD
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Undernutrition, Muscular atrophy, Muscle weight, Muscle fiber
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